幹細胞(stem cells)係指一群相對原始且尚未特化的細胞群，幹細胞研究可由最原始的受精卵（全能性幹細胞）推展至胚胎（胚胎幹細胞）與成體組織（組織幹細胞）。由於這些細胞具有自我更新（self-renew）與分化（differentiation）能力，幹細胞因此在損傷組織之細胞替代療法（cell replacement therapeutics）以及組織工程（tissue engineering）等具有廣泛前景。本課程乃著重幹細胞的學理基礎與實際運用，涵容幹細胞的生長與分化調節、幹細胞微環境（niche）、幹細胞可塑性（plasticity）、幹細胞學研究方法以及幹細胞治療等；課程且配合指定文獻的閱讀與互動討論，使學生對於現階幹細胞研究前景，有更為全面且深入的了解。Stem cells refer to a group of relatively primitive and unspecialized cells. Stem cell research can be extended from the most primitive fertilized eggs (totipotent stem cells) to embryos (embryonic stem cells) and adult tissues (tissue stem cells). Because these cells have the ability to self-renew and differentiate, stem cells have broad prospects in cell replacement therapeutics and tissue engineering for damaged tissues. This course focuses on the academic foundation and practical application of stem cells, covering the growth and differentiation regulation of stem cells, stem cell microenvironment (niche), stem cell plasticity (plasticity), stem cell research methods, and stem cell therapy. The course is also accompanied by the reading and reading of designated literature. Interactive discussions enable students to have a more comprehensive and in-depth understanding of the current prospects of stem cell research.
1. Robert Lanza, John Gearhart, Brigid Hogan, Douglas Melton, Roger Pedersen, E. Donnall Thomas, James Thomson and Sir Ian Wilmut. 2009. Essentials of Stem Cell Biology (Second Edition). Elsevier.
2. Kamran Alimoghaddam. 2013. Stem Cell Biology in Normal Life and Diseases. Intech.
3. Robert Lanza John Gearhart Brigid Hogan Douglas Melton Roger Pedersen E. Donnall Thomas James Thomson Ian Wilmut. 2009. Essentials of Stem Cell Biology. (Second Edition). Elsevier.
1. Robert Lanza, John Gearhart, Brigid Hogan, Douglas Melton, Roger Pedersen, E. Donnall Thomas, James Thomson and Sir Ian Wilmut. 2009. Essentials of Stem Cell Biology (Second Edition). Elsevier.
2. Kamran Alimoghaddam. 2013. Stem Cell Biology in Normal Life and Diseases. Intech.
3. Robert Lanza John Gearhart Brigid Hogan Douglas Melton Roger Pedersen E. Donnall Thomas James Thomson Ian Wilmut. 2009. Essentials of Stem Cell Biology. (Second Edition). Elsevier.
| 評分項目 Grading Method | 配分比例 Grading percentage | 說明 Description |
|---|---|---|
| 隨堂表現隨堂表現 Performance in class |
10 | 課程討論、出席率 |
| 期中考期中考 midterm exam |
30 | 期中考 |
| 期末考期末考 final exam |
30 | 期末考 |
| 期末報告期末報告 Final report |
30 | 期末口頭報告與討論 |
