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5365 - 蛋白化學 Protein Chemistry


教育目標 Course Target

Importance and diversity of proteins. Active and inactive conformations of proteins. Principles of molecular recognition and applications. Importance of enzyme inhibitors in the development of modern drugs. Suicide enzyme inactivators. Receptor-ligand interactions and cooperativity, allosteric enzymes, Scatchard equation and the Hill equation, enzyme mechanisms, mechanisms of selected enzymes: catalase, superoxide dismutase, carbonic anhydrase, cytochrome P450, glutathione transferase, glutathione peroxidases, restriction endonucleases, etc. Mechanisms and clinical significance of protein folding. Importance and diversity of proteins. Active and inactive conformations of proteins. Principles of molecular recognition and applications. Importance of energy inhibitors in the development of modern drugs. Suicide energy inactivators. Receptor-ligand interactions and cooperation, allosteric enzymes, Scatchard equation and the Hill equation, enzyme mechanisms, mechanisms of selected enzymes: catalase, superoxide dismutase, carbonic anhydrase, cytochrome P450, glutathione transferase, glutathione peroxidases, restriction endonucleases, etc. Mechanisms and clinical significance of protein folding.


課程概述 Course Description

介紹胜太解離平衡反應,胜太之 Ramachandran 構象分析,酵素、 蛋白因子二級及三級結構。著重介紹各類酵素(如restriction endonucleases) 與受質結合及反應機轉。
Introduction to the analysis of the equilibrium reaction of Shengtai, Ramachandran structure analysis, enzyme, Protein factor grade 2 and 3 structures. Focus on introducing various types of enzymes (such as restriction endonucleases) Combining with quality and reactor.


參考書目 Reference Books

參攷生化主要期刊,如 J. Biol. Chem., PNAS, Biochemistry, Nature, Science 等
Refer to major biochemistry journals such as J. Biol. Chem., PNAS, Biochemistry, Nature, Science, etc.


評分方式 Grading

評分項目 Grading Method 配分比例 Grading percentage 說明 Description
期中考,期末考期中考,期末考
Midterm exam, final exam
50 有小考及報告

授課大綱 Course Plan

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Course Information

Description

學分 Credit:0-3
上課時間 Course Time:Thursday/2,3,4[CH012]
授課教師 Teacher:佘 亮
修課班級 Class:化學系化生組4,碩博1,2
選課備註 Memo:先修過生物化學,大四可選
授課大綱 Course Plan: Open

選課狀態 Attendance

There're now 13 person in the class.
目前選課人數為 13 人。

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