5370 - 結構生物化學

Structural Biochemistry

教育目標 Course Target

1. Structure and ionization properties of amino acids and polypeptides. Ionization equations and calculation of the
net charge of polypeptides.
2. Secondary structures of proteins, the Ramachandran angles(dihedral angles) of peptides. Modern concepts of
molecular recognitions, receptors, receptor-ligand interactions, enzyme-substrate interactions. The Scatchard
equation.
3. Enzyme kinetics, derivation and applications of the Michaelis-Menten equation.
4. Importance of enzyme inhibitors and applications in modern drug developments.
Derivation of the equations for competitive enzyme inhibitors. Enzyme catalytic principles and mechanisms:
Coenzyme and mechanisms
5. DNA structure, major groove and minor groove figures. DNA-protein interactions,
DNA-small ligand interactions. Restriction endonuclease mechanisms.

1. Structure and ionization properties of amino acids and polypeptides. Ionization equations and calculation of the
net charge of polypeptides.
2. Secondary structures of proteins, the Ramachandran angles(dihedral angles) of peptides. Modern concepts of
molecular recognitions, receivers, receiver-ligand interactions, enzyme-substrate interactions. The Scatchard
equation.
3. Enzyme kinetics, derivation and applications of the Michaelis-Menten equation.
4. Importance of energy inhibitors and applications in modern drug developments.
Derivation of the equations for competitive enzyme inhibitors. Enzyme catalytic principles and mechanisms:
Coenzyme and mechanisms
5. DNA structure, major groove and minor groove figures. DNA-protein interactions,
DNA-small ligand interactions. Restriction endonuclease mechanisms.

參考書目 Reference Books

Major journals: Nature, PNAS, Science, JACS

Major journals: Nature, PNAS, Science, JACS

評分方式 Grading

評分項目
Grading Method
配分比例
Percentage
說明
Description
mid term and term examinations
mid term and term examinations
50 期中期末考各佔約百分之五十

授課大綱 Course Plan

點擊下方連結查看詳細授課大綱
Click the link below to view the detailed course plan

查看授課大綱 View Course Plan

相似課程 Related Courses

無相似課程 No related courses found

課程資訊 Course Information

基本資料 Basic Information

  • 課程代碼 Course Code: 5370
  • 學分 Credit: 2-0
  • 上課時間 Course Time:
    Thursday/3,4[CH012]
  • 授課教師 Teacher:
    佘 亮
  • 修課班級 Class:
    化學系4,碩博1,2
  • 選課備註 Memo:
    大四可選。
選課狀態 Enrollment Status

目前選課人數 Current Enrollment: 27 人

交換生/外籍生選課登記

請點選上方按鈕加入登記清單,再等候任課教師審核。
Add this class to your wishlist by clicking the button above.