5370 - 結構生物化學
Structural Biochemistry
教育目標 Course Target
1. Structure and ionization properties of amino acids and polypeptides. Ionization equations and calculation of the
net charge of polypeptides.
2. Secondary structures of proteins, the Ramachandran angles(dihedral angles) of peptides. Modern concepts of
molecular recognitions, receptors, receptor-ligand interactions, enzyme-substrate interactions. The Scatchard
equation.
3. Enzyme kinetics, derivation and applications of the Michaelis-Menten equation.
4. Importance of enzyme inhibitors and applications in modern drug developments.
Derivation of the equations for competitive enzyme inhibitors. Enzyme catalytic principles and mechanisms:
Coenzyme and mechanisms
5. DNA structure, major groove and minor groove figures. DNA-protein interactions,
DNA-small ligand interactions. Restriction endonuclease mechanisms.
1. Structure and ionization properties of amino acids and polypeptides. Ionization equations and calculation of the
net charge of polypeptides.
2. Secondary structures of proteins, the Ramachandran angles(dihedral angles) of peptides. Modern concepts of
molecular recognitions, receivers, receiver-ligand interactions, enzyme-substrate interactions. The Scatchard
equation.
3. Enzyme kinetics, derivation and applications of the Michaelis-Menten equation.
4. Importance of energy inhibitors and applications in modern drug developments.
Derivation of the equations for competitive enzyme inhibitors. Enzyme catalytic principles and mechanisms:
Coenzyme and mechanisms
5. DNA structure, major groove and minor groove figures. DNA-protein interactions,
DNA-small ligand interactions. Restriction endonuclease mechanisms.
參考書目 Reference Books
Major journals: Nature, PNAS, Science, JACS
Major journals: Nature, PNAS, Science, JACS
評分方式 Grading
評分項目 Grading Method |
配分比例 Percentage |
說明 Description |
---|---|---|
mid term and term examinations mid term and term examinations |
50 | 期中期末考各佔約百分之五十 |
授課大綱 Course Plan
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課程資訊 Course Information
基本資料 Basic Information
- 課程代碼 Course Code: 5370
- 學分 Credit: 2-0
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上課時間 Course Time:Thursday/3,4[CH012]
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授課教師 Teacher:佘 亮
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修課班級 Class:化學系4,碩博1,2
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選課備註 Memo:大四可選。
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