5370 - 蛋白化學

Protein Chemistry

教育目標 Course Target

最新課程概述: Importance and diversity of proteins. Active and inactive conformations of proteins. Importance of enzyme inhibitors in the development of modern drugs.Suicide enzyme inactivators. Receptor-ligand interactions and cooperativity, allosteric enzymes, Scatchard equation and the Hill equation, enzyme mechanisms, mechanisms of selected enzymes: catalase, superoxide dismutase, carbonic anhydrase, cytochrome P450, glutathione transferase, glutathione peroxidases, restriction endonucleases, etc. Mechanisms and clinical significance of protein folding.
Protein-nucleic acid interactions.

Latest course overview: Importance and diversity of proteins. Active and inactive conformations of proteins. Importance of energy inhibitors in the development of modern drugs.Suicide energy inactivators. Receptor-ligand interactions and cooperation, allosteric enzymes, Scatchard equation and the Hill equation, enzyme mechanisms, mechanisms of selected enzymes: catalase, superoxide dismutase, carbonic anhydrase, cytochrome P450, glutatthione transferase, glutatthione peroxidases, restriction endonucleases, etc. Mechanisms and clinical significance of protein folding.
Protein-nucleic acid interactions.

課程概述 Course Description

介紹胜太解離平衡反應,胜太之 Ramachandran 構象分析,酵素、

蛋白因子二級及三級結構。著重介紹各類酵素(如restriction endonucleases)

與受質結合及反應機轉。

Introduction to the analysis of the equilibrium reaction of Shengtai, Ramachandran structure analysis, enzyme,

Protein factor grade 2 and 3 structures. Focus on introducing various types of enzymes (such as restriction endonucleases)

Combining with quality and reactor.

參考書目 Reference Books

Reference: SCI papers : 如 J. Biol. Chem.,JACS, PNAS, Biochemistry, Nature, Science 等

Reference: SCI papers: such as J. Biol. Chem., JACS, PNAS, Biochemistry, Nature, Science, etc.

評分方式 Grading

評分項目
Grading Method
配分比例
Percentage
說明
Description
期中考 期末考
Midterm exam Final exam
50 期中考 期末考各50% 小考另行通知

授課大綱 Course Plan

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課程資訊 Course Information

基本資料 Basic Information

  • 課程代碼 Course Code: 5370
  • 學分 Credit: 0-3
  • 上課時間 Course Time:
    Tuesday/2,3,4[CH012]
  • 授課教師 Teacher:
    佘 亮
  • 修課班級 Class:
    化學系4,碩博1,2
  • 選課備註 Memo:
    需先修過生物化學,大四可選修
選課狀態 Enrollment Status

目前選課人數 Current Enrollment: 15 人

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