不對稱合成是指使用有機合成方式製備具有掌性(光學活性)的有機化合物，目前此類研究已經被廣泛應用於天然物與藥物合成中。不對稱合成策略分為四大類: (1) 修飾具有光學活性的天然物。(2) 分離外消旋混合物。(3) 使用掌性輔助基團或試劑建立掌性中心。(4) 使用掌性催化劑建立掌性中心。本課程教學重點分為三部分:(1) 根據所需要的掌性化合物的結構特性，設計快速及有效的合成策略。(2) 使用不同的分析儀器鑑定掌性化合物的光學純度、絕對立體組態、相對立體組態。(3) 探討文獻上具有代表性的不對稱合成方法以及其方法於天然物與藥物合成中的實際應用。Synthesis does not refer to the use of organic synthesis methods to prepare organic compounds with palm properties (optical activity). At present, this type of research has been widely used in the synthesis of natural substances and drugs. Synthetic strategies are not classified into four categories: (1) Repair natural substances with optical activity. (2) Separate the racemic mixture. (3) Use palm aid group or tests to establish palm aid center. (4) Use palm catalytic agent to establish palm centers. The focus of this course is divided into three parts: (1) Design a fast and effective synthesis strategy based on the required structural characteristics of palm compounds. (2) Use different analysers to determine the optical purity, absolute and relative three-dimensional structure of palm compounds. (3) Explore the representative non-proportional synthesis methods and their actual applications in the synthesis of natural substances and drugs.
1. Asymmetric Synthesis (Mathias Christmann and Stefan Bräse), 2012.
2. Asymmetric Synthesis of Natural Products (Ari M. P. Koskinen), 2012.
3. Catalytic Asymmetric Synthesis (Iwao Ojima), 2010.
1. Asymmetric Synthesis (Mathias Christmann and Stefan Bräse), 2012.
2. Asymmetric Synthesis of Natural Products (Ari M. P. Koskinen), 2012.
3. Catalytic Asymmetric Synthesis (Iwao Ojima), 2010.
| 評分項目 Grading Method | 配分比例 Grading percentage | 說明 Description |
|---|---|---|
| 期中考期中考 Midterm exam |
30 | |
| 期末考期末考 Final exam |
30 | |
| 上台發表上台發表 Posted on stage |
30 | |
| 出席率出席率 Attendance rate |
10 |
