本課程介紹蛋白質在生命科學中的重要性及在醫學上的重要性及應用。將給予同學較廣泛深入探討蛋白質的生物有機化學及生物物理的性質，有利於大學畢業後參加生物醫學及生化研究。課程內容如下:
Importance and diversity of proteins. Active and inactive conformations of proteins. Importance of enzyme inhibitors in the development of modern drugs.Suicide enzyme inactivators. Receptor-ligand interactions and cooperativity, allosteric enzymes, Scatchard equation and the Hill equation, enzyme mechanisms, mechanisms of selected enzymes: catalase, superoxide dismutase, carbonic anhydrase, cytochrome P450, Glutathione transferase, glutathione peroxidases, restriction endonucleases, etc. Mechanisms and clinical significance of protein folding.
This course introduces the importance of proteins in life sciences and their importance and applications in medicine. It will provide students with a broader and in-depth exploration of the bioorganic chemistry and biophysical properties of proteins, which will help students participate in biomedical and biochemical research after graduation. The course content is as follows:
Importance and inactive conformations of proteins. Importance of enzyme inhibitors in the development of modern drugs. Suicide enzyme inactivators. Receptor-ligand interactions and cooperativity, allosteric enzymes, Scatchard equation and the Hill equation, enzyme mechanisms, diversity mechanisms of selected enzymes: catalase, superoxide dismutase, carbonic anhydrase, cytochrome P450, Glutathione transferase, glutathione peroxidases, restriction endonucleases, etc. Mechanisms and clinical significance of protein folding.
介紹胜太解離平衡反應，胜太之 Ramachandran 構象分析，酵素、
蛋白因子二級及三級結構。著重介紹各類酵素(如restriction endonucleases)
與受質結合及反應機轉。
Introduction to Shouta’s dissociation equilibrium reaction, Shouta’s Ramachandran conformation analysis, enzymes,
Secondary and tertiary structure of protein factors. Focus on various types of enzymes (such as restriction endonucleases)
Combine with substrate and reaction mechanism.
Biochemistry (Van Holde)
References from major journal such as Nature, Science, JACS, PNAS
biochemistry (van hold E)
| 評分項目 Grading Method | 配分比例 Grading percentage | 說明 Description |
|---|---|---|
| 期中考期中考 midterm exam |
50 | 期末考 50% |
