不對稱合成是指使用有機合成方式製備具有掌性(光學活性)的有機化合物，目前此類研究已經被廣泛應用於天然物與藥物合成中。不對稱合成策略分為四大類: (1) 修飾具有光學活性的天然物。(2) 分離外消旋混合物。(3) 使用掌性輔助基團或試劑建立掌性中心。(4) 使用掌性催化劑建立掌性中心。本課程教學重點分為三部分:(1) 根據所需要的掌性化合物的結構特性，設計快速及有效的合成策略。(2) 使用不同的分析儀器鑑定掌性化合物的光學純度、絕對立體組態、相對立體組態。(3) 探討文獻上具有代表性的不對稱合成方法以及其方法於天然物與藥物合成中的實際應用。Asymmetric synthesis refers to the use of organic synthesis methods to prepare chiral (optically active) organic compounds. Currently, this type of research has been widely used in the synthesis of natural products and drugs. Asymmetric synthesis strategies are divided into four major categories: (1) Modification of optically active natural products. (2) Separate racemic mixtures. (3) Use chiral auxiliary groups or reagents to establish chiral centers. (4) Use chiral catalysts to establish chiral centers. The teaching focus of this course is divided into three parts: (1) Design a fast and effective synthesis strategy based on the structural characteristics of the required chiral compounds. (2) Use different analytical instruments to identify the optical purity, absolute stereoconfiguration, and relative stereoconfiguration of chiral compounds. (3) Discuss the representative asymmetric synthesis methods in the literature and their practical applications in the synthesis of natural products and drugs.
1. Asymmetric Synthesis (Mathias Christmann and Stefan Bräse), 2012.
2. Asymmetric Synthesis of Natural Products (Ari M. P. Koskinen), 2012.
3. Catalytic Asymmetric Synthesis (Iwao Ojima), 2010.
1. Asymmetric Synthesis (Mathias Christmann and Stefan Bräse), 2012.
2. Asymmetric Synthesis of Natural Products (Ari M. P. Koskinen), 2012.
3. Catalytic Asymmetric Synthesis (Iwao Ojima), 2010.
| 評分項目 Grading Method | 配分比例 Grading percentage | 說明 Description |
|---|---|---|
| 期中報告期中報告 interim report |
30 | |
| 期末考期末考 final exam |
40 | |
| 出席率出席率 Attendance |
30 |
