課程目標首先讓同學認識癌症本身在生物學上的本質, 並學習癌症的發生原因及機制, 包括基因本身的影響, 病毒的影響, 細胞蛋白質變異的影響. 並將探討分子層次的轉變如何改變細胞的表現行為進而導致癌症發生, 包括細胞週期(cell cycle), 細胞移行(cell motility)及轉移(metastasis). 本課程也將介紹臨床癌症病理學以及治療的處理方式.本課程涵蓋主題如下:
1.The nature of cancer
2.Tumor viruses
3.Cellular oncogene
4.Growth factors and their receptors
5.Cytoplasmic signaling circuitry programs many of the traits of cancer
6.Tumor supressor gene
7.pRb and control of cell cycle
8.p53 and apoptosis
9.Cell immortalization and tumorgenesis
10.Multistep tumorgenesis
11.Maintenance of genomic integrity and the development of cancer
12.Heterotypic interactions and the biology of angiogenesis
13.Moving out: invasion and metastasis
14.The rational treatment of cancerThe goal of the course is to first let students understand the biological nature of cancer itself, and learn the causes and mechanisms of cancer, including the impact of genes themselves, the impact of viruses, and the impact of cellular protein mutations. It will also explore how changes at the molecular level change cells The behaviors that lead to cancer development include cell cycle, cell motility and metastasis. This course will also introduce clinical cancer pathology and treatment methods. This course covers the following topics:
1.The nature of cancer
2.Tumor viruses
3.Cellular oncogene
4.Growth factors and their receptors
5.Cytoplasmic signaling circuitry programs many of the traits of cancer
6.Tumor suppressor gene
7.pRb and control of cell cycle
8.p53 and apoptosis
9.Cell immortalization and tumorogenesis
10.Multistep tumorogenesis
11.Maintenance of genomic integrity and the development of cancer
12.Heterotypic interactions and the biology of angiogenesis
13.Moving out: invasion and metastasis
14.The rational treatment of cancer
瞭解癌症生物學的內涵、機制、及發展近況。
Understand the connotation, mechanism, and recent development of cancer biology.
Weinberg, RA. The Biology of Cancer. Garland Science, Taylor& Francis Group, LLC. 2014.
Weinberg, RA. the biology of cancer. Garland science, Taylor& Francis group, LLC. 2014.
| 評分項目 Grading Method | 配分比例 Grading percentage | 說明 Description |
|---|---|---|
| 期中考期中考 midterm exam |
25 | |
| 期末考期末考 final exam |
25 | |
| 小考小考 Quiz |
30 | 兩次, 每次15% |
| 心得報告心得報告 Experience report |
10 | |
| 出席率及態度出席率及態度 Attendance and Attitude |
10 |
