1、生物資訊學為跨領域學科，其學術論文的閱讀，難度相對較高。本課程將選擇若干學術論文，由授課教師詳細解說，並營照成一門師生充分討論、互動的課程。
2、本課程的另一目標在讓學生了解若干較新的學術問題。
3、本學期將選擇與 Sequence libraries that cover all k-mers 相關的學術論文。
4、該主題的意義： Protein-DNA， protein-RNA， 與 protein-peptide 的binding，驅動了幾乎所有的細胞活動。具備Sequence libraries that cover all k-mers，可以全面且不偏地研究這些binding。
5、該主題面臨的挑戰：較大的k值，可以更深入地聊解這些binding，但卻面臨了一個難題：k-mers 的個數，會隨著k值的增大，而呈指數型態增加，有限的實驗設施因而無法容納。
1. Biological information is a cross-domain subject, and the difficulty of reading academic papers is relatively high. This course will select several academic papers, which are explained in detail by the teacher, and will be guided into a course that teachers and students can fully discuss and interact.
2. Another goal of this course is to let students understand several newer academic issues.
3. During this period, academic papers related to Sequence libraries that cover all k-mers will be selected.
4. The meaning of the topic: Protein-DNA, protein-RNA, and protein-peptide binding drive almost all cell activities. With Sequence libraries that cover all k-mers, these bindings can be studied comprehensively and unbiasedly.
5. Challenges in this topic: A larger k value can explain these bindings in depth, but face a difficult problem: the number of k-mers will increase exponentially as the k value increases, and the limited experimental facilities are therefore unacceptable.
學術論文
Academic essay
| 評分項目 Grading Method | 配分比例 Grading percentage | 說明 Description |
|---|---|---|
| 期中考期中考 Midterm exam |
40 | |
| 期末考期末考 Final exam |
40 | |
| 課堂表現課堂表現 Classroom performance |
20 |
